| TM | Name | POS | GP | CMP | ATT | CMP% | YDS | AVG | YDS/G | LNG | TD | INT | SACK | SYL | QBR | RTG |
| ARI | * MURRAY | QB | 5 | 110 | 161 | 68.3 | 962 | 6 | 192.4 | 45 | 6 | 3 | 16 | 111 | 44.1 | 88.6 |
| ATL | PENIX | QB | 6 | 119 | 195 | 61 | 1,409 | 7.2 | 234.8 | 69 | 5 | 3 | 9 | 70 | 49.1 | 85.2 |
| ATL | COUSINS | QB | 2 | 26 | 38 | 68.4 | 202 | 5.3 | 101 | 25 | 0 | 0 | 1 | 5 | 32.6 | 81.3 |
| BAL | JACKSON | QB | 4 | 68 | 95 | 71.6 | 869 | 9.1 | 217.3 | 41 | 10 | 1 | 15 | 103 | 75.7 | 130.5 |
| BAL | RUSH | QB | 4 | 34 | 52 | 65.4 | 303 | 5.8 | 75.8 | 56 | 0 | 4 | 1 | 16 | 29.2 | 48.8 |
| BAL | HUNTLEY | QB | 2 | 27 | 37 | 73 | 254 | 6.9 | 127 | 36 | 1 | 0 | 6 | 31 | 85.2 | 100.5 |
| BUF | ALLEN | QB | 7 | 134 | 197 | 68 | 1,560 | 7.9 | 222.9 | 54 | 12 | 4 | 14 | 85 | 62 | 103.6 |
| BUF | TRUBISKY | QB | 2 | 3 | 6 | 50 | 54 | 9 | 27 | 32 | 0 | 0 | 0 | 0 | 98.7 | 81.3 |
| CAR | YOUNG | QB | 7 | 138 | 224 | 61.6 | 1,288 | 5.8 | 184 | 40 | 11 | 5 | 11 | 91 | 45.3 | 84.4 |
| CAR | DALTON | QB | 4 | 25 | 37 | 67.6 | 293 | 7.9 | 73.3 | 33 | 1 | 1 | 8 | 54 | 11.5 | 89.1 |
| CHI | WILLIAMS | QB | 7 | 138 | 223 | 61.9 | 1,636 | 7.3 | 233.7 | 65 | 9 | 4 | 12 | 84 | 52.9 | 90.2 |
| CIN | BROWNING | QB | 4 | 80 | 124 | 64.5 | 757 | 6.1 | 189.3 | 64 | 6 | 8 | 9 | 60 | 33.5 | 70.5 |
| CIN | BURROW | QB | 2 | 21 | 36 | 58.3 | 189 | 5.3 | 94.5 | 25 | 2 | 0 | 5 | 26 | 57.6 | 91.1 |
| CIN | FLACCO | QB | 7 | 174 | 286 | 60.8 | 1,599 | 5.6 | 228.4 | 44 | 9 | 6 | 13 | 80 | 42.7 | 77.8 |
| CLE | GABRIEL | QB | 6 | 85 | 142 | 59.9 | 702 | 4.9 | 117 | 24 | 5 | 2 | 11 | 71 | 25.8 | 78.4 |
| DAL | PRESCOTT | QB | 8 | 204 | 290 | 70.3 | 2,069 | 7.1 | 258.6 | 74 | 16 | 5 | 10 | 58 | 79.5 | 101.6 |
| DAL | MILTON | QB | 2 | 6 | 9 | 66.7 | 99 | 11 | 49.5 | 35 | 1 | 1 | 0 | 0 | 92.4 | 100.9 |
| DEN | NIX | QB | 8 | 179 | 285 | 62.8 | 1,803 | 6.3 | 225.4 | 52 | 15 | 5 | 8 | 50 | 58.7 | 91 |
| DET | GOFF | QB | 7 | 152 | 203 | 74.9 | 1,631 | 8 | 233 | 64 | 15 | 3 | 13 | 69 | 66.9 | 116.4 |
| GB | LOVE | QB | 7 | 151 | 213 | 70.9 | 1,798 | 8.4 | 256.9 | 59 | 13 | 2 | 10 | 83 | 73.5 | 112.8 |
| HOU | STROUD | QB | 7 | 155 | 232 | 66.8 | 1,623 | 7 | 231.9 | 50 | 11 | 5 | 15 | 139 | 63.1 | 93.7 |
| IND | JONES | QB | 8 | 173 | 243 | 71.2 | 2,062 | 8.5 | 257.8 | 75 | 13 | 3 | 9 | 64 | 79.3 | 109.5 |
| JAX | LAWRENCE | QB | 7 | 152 | 259 | 58.7 | 1,620 | 6.3 | 231.4 | 46 | 9 | 5 | 20 | 114 | 41.8 | 80.6 |
| KC | MAHOMES | QB | 8 | 189 | 282 | 67 | 2,099 | 7.4 | 262.4 | 49 | 17 | 4 | 14 | 85 | 76.3 | 103.1 |
| LAC | HERBERT | QB | 8 | 201 | 296 | 67.9 | 2,140 | 7.2 | 267.5 | 60 | 16 | 7 | 22 | 136 | 68.8 | 97 |
| LAC | LANCE | QB | 1 | 3 | 4 | 75 | 44 | 11 | 44 | 21 | 0 | 0 | 1 | 5 | 55.5 | 110.4 |
| LAR | STAFFORD | QB | 7 | 160 | 242 | 66.1 | 1,866 | 7.7 | 266.6 | 88 | 17 | 2 | 11 | 69 | 65.5 | 109.3 |
| LV | SMITH | QB | 7 | 133 | 202 | 65.8 | 1,417 | 7 | 202.4 | 61 | 7 | 10 | 19 | 146 | 34.4 | 77.1 |
| MIA | TAGOVAILOA | QB | 8 | 159 | 231 | 68.8 | 1,518 | 6.6 | 189.8 | 47 | 15 | 10 | 16 | 88 | 46.6 | 90.4 |
| MIA | EWERS | QB | 1 | 5 | 8 | 62.5 | 53 | 6.6 | 53 | 40 | 0 | 0 | 2 | 20 | 21.4 | 81.8 |
| MIN | WENTZ | QB | 5 | 110 | 169 | 65.1 | 1,216 | 7.2 | 243.2 | 81 | 6 | 5 | 19 | 125 | 39.4 | 85.8 |
| MIN | CARTHY | QB | 2 | 24 | 41 | 58.5 | 301 | 7.3 | 150.5 | 50 | 2 | 3 | 9 | 47 | 21.5 | 67.2 |
| MIN | BROSMER | QB | 3 | 5 | 8 | 62.5 | 42 | 5.3 | 14 | 20 | 0 | 0 | 0 | 0 | 18.3 | 76 |
| NE | MAYE | QB | 8 | 170 | 226 | 75.2 | 2,026 | 9 | 253.3 | 55 | 15 | 3 | 28 | 114 | 76.3 | 118.7 |
| NO | RATTLER | QB | 8 | 174 | 256 | 68 | 1,586 | 6.2 | 198.3 | 87 | 8 | 5 | 18 | 104 | 50.8 | 86.8 |
| NO | SHOUGH | QB | 2 | 17 | 32 | 53.1 | 128 | 4 | 64 | 16 | 0 | 1 | 2 | 18 | 7.5 | 50 |
| NYG | DART | QB | 7 | 85 | 142 | 59.9 | 984 | 6.9 | 140.6 | 44 | 8 | 3 | 17 | 59 | 61.4 | 90.8 |
| NYG | WILSON | QB | 5 | 66 | 112 | 58.9 | 786 | 7 | 157.2 | 52 | 3 | 3 | 8 | 53 | 31.3 | 78.2 |
| NYJ | FIELDS | QB | 7 | 107 | 167 | 64.1 | 1,089 | 6.5 | 155.6 | 34 | 5 | 0 | 22 | 169 | 38.1 | 92.6 |
| NYJ | TAYLOR | QB | 3 | 43 | 69 | 62.3 | 379 | 5.5 | 126.3 | 35 | 3 | 3 | 9 | 51 | 39.9 | 73.3 |
| PHI | HURTS | QB | 8 | 151 | 215 | 70.2 | 1,677 | 7.8 | 209.6 | 79 | 15 | 1 | 25 | 135 | 67 | 114.4 |
| PIT | RODGERS | QB | 7 | 142 | 208 | 68.3 | 1,489 | 7.2 | 212.7 | 80 | 16 | 5 | 12 | 81 | 52 | 104.4 |
| SEA | DARNOLD | QB | 7 | 131 | 192 | 68.2 | 1,754 | 9.1 | 250.6 | 61 | 12 | 4 | 9 | 58 | 72.2 | 109.2 |
| SF | JONES | QB | 6 | 149 | 226 | 65.9 | 1,597 | 7.1 | 266.2 | 56 | 8 | 5 | 14 | 94 | 59 | 89 |
| SF | PURDY | QB | 2 | 48 | 73 | 65.8 | 586 | 8 | 293 | 45 | 4 | 4 | 2 | 15 | 67.2 | 85.8 |
| TB | MAYFIELD | QB | 8 | 172 | 269 | 63.9 | 1,919 | 7.1 | 239.9 | 77 | 13 | 2 | 17 | 120 | 61 | 98.1 |
| TEN | WARD | QB | 8 | 158 | 274 | 57.7 | 1,615 | 5.9 | 201.9 | 47 | 5 | 6 | 34 | 268 | 25.7 | 71.7 |
| WSH | DANIELS | QB | 5 | 89 | 146 | 61 | 1,031 | 7.1 | 206.2 | 50 | 8 | 1 | 13 | 58 | 50.9 | 97.7 |
| WSH | MARIOTA | QB | 4 | 56 | 88 | 63.6 | 639 | 7.3 | 159.8 | 56 | 4 | 4 | 7 | 39 | 59.9 | 81.6 |