| TM | QB | POS | GP | CMP | ATT | CMP% | YDS | AVG | YDS/G | LNG | TD | INT | SACK | SYL | QBR | RTG |
| ARI | BRISSETT | QB | 8 | 175 | 262 | 66.8 | 1,887 | 7.2 | 235.9 | 50 | 11 | 3 | 24 | 187 | 40 | 97 |
| ARI | MURRAY | QB | 5 | 110 | 161 | 68.3 | 962 | 6 | 192.4 | 45 | 6 | 3 | 16 | 111 | 44.8 | 88.6 |
| ATL | PENIX | QB | 9 | 166 | 276 | 60.1 | 1,982 | 7.2 | 220.2 | 69 | 9 | 3 | 13 | 101 | 56.4 | 88.5 |
| ATL | COUSINS | QB | 4 | 48 | 75 | 64 | 449 | 6 | 112.3 | 49 | 2 | 1 | 4 | 23 | 33.8 | 83.7 |
| BAL | JACKSON | QB | 8 | 130 | 195 | 66.7 | 1,595 | 8.2 | 199.4 | 45 | 15 | 3 | 24 | 162 | 63.2 | 111 |
| BAL | RUSH | QB | 4 | 34 | 52 | 65.4 | 303 | 5.8 | 75.8 | 56 | 0 | 4 | 1 | 16 | 29.2 | 48.8 |
| BAL | HUNTLEY | QB | 2 | 27 | 37 | 73 | 254 | 6.9 | 127 | 36 | 1 | 0 | 6 | 31 | 84.5 | 100.5 |
| BUF | ALLEN | QB | 11 | 228 | 327 | 69.7 | 2709 | 8.3 | 246.3 | 54 | 18 | 9 | 28 | 182 | 58.1 | 101.6 |
| CAR | YOUNG | QB | 11 | 215 | 343 | 62.7 | 2,131 | 6.2 | 193.7 | 54 | 15 | 9 | 20 | 150 | 42.8 | 83.8 |
| CAR | DALTON | QB | 4 | 25 | 37 | 67.6 | 293 | 7.9 | 73.3 | 33 | 1 | 1 | 8 | 54 | 11 | 89.1 |
| CHI | WILLIAMS | QB | 11 | 213 | 360 | 59.2 | 2,568 | 7.1 | 233.5 | 65 | 16 | 4 | 17 | 116 | 55.3 | 91.3 |
| CIN | FLACCO | QB | 10 | 247 | 410 | 60.2 | 2,451 | 6 | 245.1 | 44 | 15 | 10 | 18 | 118 | 42.9 | 79.2 |
| CIN | BROWNING | QB | 5 | 81 | 125 | 64.8 | 771 | 6.2 | 154.2 | 64 | 6 | 8 | 9 | 60 | 33.8 | 71.1 |
| CIN | BURROW | QB | 2 | 21 | 36 | 58.3 | 189 | 5.3 | 94.5 | 25 | 2 | 0 | 5 | 26 | 61.3 | 91.1 |
| CLE | GABRIEL | QB | 8 | 109 | 184 | 59.2 | 937 | 5.1 | 117.1 | 26 | 7 | 2 | 18 | 125 | 30.4 | 80.8 |
| CLE | SANDERS | QB | 2 | 15 | 36 | 41.7 | 256 | 7.1 | 128 | 66 | 1 | 2 | 3 | 30 | 4.5 | 52.5 |
| DAL | PRESCOTT | QB | 11 | 276 | 398 | 69.3 | 2941 | 7.4 | 267.4 | 74 | 23 | 7 | 17 | 105 | 74 | 102.6 |
| DAL | MILTON | QB | 2 | 6 | 9 | 66.7 | 99 | 11 | 49.5 | 35 | 1 | 1 | 0 | 0 | 92.1 | 100.9 |
| DEN | NIX | QB | 11 | 237 | 387 | 61.2 | 2421 | 6.3 | 220.1 | 52 | 18 | 8 | 12 | 73 | 53.5 | 86.1 |
| DET | GOFF | QB | 11 | 244 | 352 | 69.3 | 2,769 | 7.9 | 251.7 | 64 | 23 | 5 | 23 | 147 | 54.8 | 108.5 |
| GB | LOVE | QB | 11 | 224 | 331 | 67.7 | 2,560 | 7.7 | 232.7 | 59 | 15 | 3 | 17 | 126 | 70 | 102 |
| HOU | STROUD | QB | 8 | 161 | 242 | 66.5 | 1,702 | 7 | 212.8 | 50 | 11 | 5 | 17 | 148 | 65.6 | 93.4 |
| HOU | MILLS | QB | 5 | 88 | 150 | 58.7 | 879 | 5.9 | 175.8 | 54 | 5 | 1 | 8 | 60 | 44.6 | 83.7 |
| IND | JONES | QB | 11 | 242 | 350 | 69.1 | 2,840 | 8.1 | 258.2 | 75 | 17 | 7 | 21 | 152 | 65.9 | 101.4 |
| JAX | LAWRENCE | QB | 11 | 220 | 368 | 59.8 | 2,407 | 6.5 | 218.8 | 46 | 14 | 11 | 29 | 176 | 42.9 | 79.4 |
| KC | MAHOMES | QB | 11 | 262 | 407 | 64.4 | 2977 | 7.3 | 270.6 | 61 | 18 | 7 | 24 | 142 | 71.9 | 93.8 |
| LAC | HERBERT | QB | 11 | 250 | 376 | 66.5 | 2,691 | 7.2 | 244.6 | 60 | 19 | 9 | 35 | 213 | 60.4 | 94.2 |
| LAR | STAFFORD | QB | 11 | 248 | 373 | 66.5 | 2,830 | 7.6 | 257.3 | 88 | 30 | 2 | 15 | 98 | 69.7 | 113.7 |
| LV | SMITH | QB | 11 | 235 | 353 | 66.6 | 2,367 | 6.7 | 215.2 | 61 | 13 | 13 | 41 | 291 | 29.3 | 82.4 |
| MIA | TAGOVAILOA | QB | 11 | 213 | 312 | 68.3 | 2,123 | 6.8 | 193 | 47 | 17 | 13 | 21 | 133 | 43.5 | 88.1 |
| MIN | WENTZ | QB | 5 | 110 | 169 | 65.1 | 1,216 | 7.2 | 243.2 | 81 | 6 | 5 | 19 | 125 | 43.2 | 85.8 |
| MIN | CARTHY | QB | 6 | 86 | 159 | 54.1 | 929 | 5.8 | 154.8 | 62 | 6 | 10 | 20 | 112 | 24.8 | 57.9 |
| NE | MAYE | QB | 12 | 252 | 355 | 71 | 3130 | 8.8 | 260.8 | 72 | 21 | 6 | 37 | 172 | 72.7 | 110.7 |
| NO | RATTLER | QB | 8 | 174 | 256 | 68 | 1586 | 6.2 | 198.3 | 87 | 8 | 5 | 18 | 104 | 49.8 | 86.8 |
| NO | SHOUGH | QB | 5 | 81 | 126 | 64.3 | 829 | 6.6 | 165.8 | 62 | 3 | 3 | 10 | 72 | 41.3 | 81.1 |
| NYG | DART | QB | 9 | 128 | 204 | 62.7 | 1417 | 6.9 | 157.4 | 44 | 10 | 3 | 21 | 83 | 64.7 | 93.5 |
| NYG | WILSON | QB | 6 | 69 | 119 | 58 | 831 | 7 | 138.5 | 52 | 3 | 3 | 10 | 66 | 27.3 | 77.4 |
| NYG | WINSTON | QB | 2 | 37 | 65 | 56.9 | 567 | 8.7 | 283.5 | 42 | 2 | 2 | 3 | 11 | 74.4 | 83.3 |
| NYJ | FIELDS | QB | 9 | 128 | 204 | 62.7 | 1259 | 6.2 | 139.9 | 42 | 7 | 1 | 27 | 192 | 38.1 | 89.5 |
| NYJ | TAYLOR | QB | 4 | 60 | 97 | 61.9 | 601 | 6.2 | 150.3 | 40 | 4 | 4 | 12 | 69 | 46.5 | 76 |
| PHI | HURTS | QB | 11 | 207 | 308 | 67.2 | 2284 | 7.4 | 207.6 | 79 | 17 | 1 | 27 | 159 | 58.8 | 106 |
| PIT | RODGERS | QB | 10 | 192 | 289 | 66.4 | 1969 | 6.8 | 196.9 | 80 | 19 | 7 | 19 | 121 | 43.8 | 97.7 |
| PIT | RUDOLPH | QB | 4 | 38 | 49 | 77.6 | 310 | 6.3 | 77.5 | 28 | 2 | 1 | 2 | 12 | 46.5 | 98.1 |
| SEA | DARNOLD | QB | 11 | 207 | 298 | 69.5 | 2785 | 9.3 | 253.2 | 67 | 19 | 10 | 11 | 67 | 69.2 | 106.2 |
| SF | JONES | QB | 9 | 201 | 289 | 69.6 | 2151 | 7.4 | 239 | 56 | 13 | 6 | 16 | 108 | 64.6 | 97.4 |
| SF | PURDY | QB | 4 | 90 | 131 | 68.7 | 979 | 7.5 | 244.8 | 45 | 8 | 7 | 3 | 29 | 65.3 | 88.6 |
| TB | MAYFIELD | QB | 11 | 225 | 359 | 62.7 | 2406 | 6.7 | 218.7 | 77 | 18 | 5 | 22 | 155 | 60.9 | 93.1 |
| TEN | WARD | QB | 11 | 222 | 374 | 59.4 | 2210 | 5.9 | 200.9 | 47 | 7 | 6 | 45 | 342 | 33.2 | 75.7 |
| WSH | DANIELS | QB | 6 | 105 | 168 | 62.5 | 1184 | 7 | 197.3 | 50 | 8 | 2 | 17 | 78 | 51.2 | 94.4 |
| WSH | MARIOTA | QB | 7 | 92 | 140 | 65.7 | 1065 | 7.6 | 152.1 | 56 | 7 | 5 | 10 | 63 | 58.8 | 90.3 |