| SHOW | TM | QB | POS | GP | CMP | ATT | CMP% | YDS | AVG | YDS/G | LNG | TD | INT | SACK | SYL | QBR | RTG |
| MORE | ARI | BRISSETT | QB | 13 | 293 | 454 | 64.5 | 3,123 | 6.9 | 240.2 | 50 | 21 | 7 | 37 | 255 | 41.3 | 93.5 |
| REPLACE | ARI | MURRAY | QB | 5 | 110 | 161 | 68.3 | 962 | 6 | 192.4 | 45 | 6 | 3 | 16 | 111 | 46.5 | 88.6 |
| SF/SAN | ATL | PENIX | QB | 9 | 166 | 276 | 60.1 | 1,982 | 7.2 | 220.2 | 69 | 9 | 3 | 13 | 101 | 56.9 | 88.5 |
| SORT | ATL | COUSINS | QB | 9 | 148 | 237 | 62.4 | 1541 | 6.5 | 171.2 | 49 | 9 | 4 | 9 | 58 | 52.2 | 86.8 |
| ALPHA | BAL | JACKSON | QB | 12 | 181 | 284 | 63.7 | 2,311 | 8.1 | 192.6 | 45 | 18 | 6 | 33 | 223 | 63.3 | 101.4 |
| NOCUT | BAL | HUNTLEY | QB | 5 | 52 | 67 | 77.6 | 426 | 6.4 | 85.2 | 36 | 2 | 0 | 8 | 38 | 81 | 103.1 |
| SAVE | BUF | ALLEN | QB | 16 | 319 | 460 | 69.3 | 3668 | 8 | 229.3 | 54 | 25 | 10 | 40 | 298 | 65.1 | 102.2 |
| 4 CHNG | CAR | YOUNG | QB | 15 | 280 | 443 | 63.2 | 2745 | 6.2 | 183 | 54 | 21 | 10 | 27 | 202 | 48 | 87 |
| PST | CHI | WILLIAMS | QB | 16 | 310 | 535 | 57.9 | 3,730 | 7 | 233.1 | 65 | 25 | 6 | 23 | 158 | 58.1 | 90.3 |
| TO QB1 | CIN | BURROW | QB | 7 | 144 | 220 | 65.5 | 1,573 | 7.2 | 224.7 | 43 | 14 | 4 | 15 | 99 | 63.2 | 100.1 |
| CIN | BROWNING | QB | 5 | 81 | 125 | 64.8 | 771 | 6.2 | 154.2 | 64 | 6 | 8 | 9 | 60 | 35.6 | 71.1 | |
| CLE | FLACCO | QB | 12 | 251 | 416 | 60.3 | 2,479 | 6 | 206.6 | 44 | 15 | 10 | 18 | 118 | 40.9 | 79.2 | |
| CLE | SANDERS | QB | 7 | 109 | 190 | 57.4 | 1289 | 6.8 | 184.1 | 66 | 7 | 10 | 17 | 135 | 20.2 | 68.5 | |
| CLE | GABRIEL | QB | 10 | 110 | 185 | 59.5 | 937 | 5.1 | 93.7 | 26 | 7 | 2 | 19 | 127 | 31.3 | 80.8 | |
| DAL | PRESCOTT | QB | 16 | 397 | 589 | 67.4 | 4,482 | 7.6 | 280.1 | 86 | 30 | 10 | 31 | 208 | 71.9 | 99.9 | |
| DEN | NIX | QB | 16 | 374 | 589 | 63.5 | 3,790 | 6.4 | 236.9 | 52 | 25 | 11 | 18 | 102 | 58.3 | 88.2 | |
| DET | GOFF | QB | 16 | 366 | 536 | 68.3 | 4233 | 7.9 | 264.6 | 64 | 33 | 7 | 36 | 244 | 57.2 | 107 | |
| GB | LOVE | QB | 15 | 291 | 439 | 66.3 | 3,381 | 7.7 | 225.4 | 59 | 23 | 6 | 21 | 169 | 73.4 | 101.2 | |
| GB | WILLIS | QB | 4 | 30 | 35 | 85.7 | 422 | 12.1 | 105.5 | 40 | 3 | 0 | 3 | 15 | 93.5 | 145.5 | |
| HOU | STROUD | QB | 13 | 259 | 400 | 64.8 | 2,872 | 7.2 | 220.9 | 75 | 18 | 8 | 23 | 189 | 61.9 | 92.6 | |
| HOU | MILLS | QB | 5 | 88 | 150 | 58.7 | 879 | 5.9 | 175.8 | 54 | 5 | 1 | 8 | 60 | 46.8 | 83.7 | |
| IND | JONES | QB | 13 | 261 | 384 | 68 | 3,101 | 8.1 | 238.5 | 75 | 19 | 8 | 22 | 158 | 63.5 | 100.2 | |
| IND | RIVERS | QB | 3 | 58 | 92 | 63 | 544 | 5.9 | 181.3 | 33 | 4 | 3 | 5 | 37 | 39.3 | 80.2 | |
| JAX | LAWRENCE | QB | 16 | 319 | 530 | 60.2 | 3,752 | 7.1 | 234.5 | 63 | 26 | 12 | 39 | 231 | 56.6 | 88.7 | |
| KC | MAHOMES | QB | 14 | 315 | 502 | 62.7 | 3,587 | 7.1 | 256.2 | 61 | 22 | 11 | 34 | 193 | 68.7 | 89.6 | |
| LAC | HERBERT | QB | 16 | 340 | 512 | 66.4 | 3727 | 7.3 | 232.9 | 60 | 26 | 13 | 54 | 301 | 60.2 | 94.1 | |
| LAR | STAFFORD | QB | 16 | 363 | 557 | 65.2 | 4,448 | 8 | 278 | 88 | 42 | 8 | 22 | 143 | 70.1 | 108.8 | |
| LV | SMITH | QB | 15 | 302 | 448 | 67.4 | 3,025 | 6.8 | 201.7 | 61 | 19 | 17 | 55 | 405 | 34.1 | 84.7 | |
| MIA | TAGOVAILOA | QB | 14 | 260 | 384 | 67.7 | 2,660 | 6.9 | 190 | 47 | 20 | 15 | 30 | 195 | 37.3 | 88.5 | |
| MIA | EWERS | QB | 3 | 39 | 60 | 65 | 485 | 8.1 | 161.7 | 63 | 2 | 2 | 4 | 39 | 31.2 | 87.2 | |
| MIN | CARTHY | QB | 9 | 126 | 220 | 57.3 | 1,450 | 6.6 | 161.1 | 62 | 11 | 12 | 27 | 149 | 33.4 | 71.2 | |
| MIN | WENTZ | QB | 5 | 110 | 169 | 65.1 | 1216 | 7.2 | 243.2 | 81 | 6 | 5 | 19 | 125 | 45.3 | 85.8 | |
| NE | MAYE | QB | 16 | 340 | 474 | 71.7 | 4203 | 8.9 | 262.7 | 72 | 30 | 8 | 47 | 201 | 76.5 | 112.9 | |
| NO | SHOUGH | QB | 10 | 198 | 292 | 67.8 | 2125 | 7.3 | 212.5 | 62 | 9 | 5 | 27 | 168 | 48.3 | 92.1 | |
| NO | RATTLER | QB | 9 | 174 | 257 | 67.7 | 1586 | 6.2 | 176.2 | 87 | 8 | 5 | 18 | 104 | 49.7 | 86.5 | |
| NYG | DART | QB | 13 | 194 | 307 | 63.2 | 2042 | 6.7 | 157.1 | 44 | 13 | 5 | 31 | 141 | 58.1 | 89.8 | |
| NYG | WILSON | QB | 6 | 69 | 119 | 58 | 831 | 7 | 138.5 | 52 | 3 | 3 | 10 | 66 | 25.1 | 77.4 | |
| NYG | WINSTON | QB | 3 | 37 | 66 | 56.1 | 567 | 8.6 | 189 | 42 | 2 | 2 | 3 | 11 | 68.6 | 82.1 | |
| NYJ | FIELDS | QB | 9 | 128 | 204 | 62.7 | 1259 | 6.2 | 139.9 | 42 | 7 | 1 | 27 | 192 | 38.1 | 89.5 | |
| NYJ | TAYLOR | QB | 6 | 80 | 134 | 59.7 | 779 | 5.8 | 129.8 | 52 | 5 | 5 | 14 | 82 | 51.6 | 72.9 | |
| NYJ | COOK | QB | 4 | 77 | 131 | 58.8 | 679 | 5.2 | 169.8 | 26 | 1 | 7 | 18 | 118 | 10 | 52.9 | |
| PHI | HURTS | QB | 16 | 294 | 454 | 64.8 | 3224 | 7.1 | 201.5 | 79 | 25 | 6 | 32 | 181 | 55.3 | 98.5 | |
| PIT | RODGERS | QB | 15 | 296 | 451 | 65.6 | 3028 | 6.7 | 201.9 | 80 | 23 | 7 | 27 | 176 | 41.9 | 95.3 | |
| SAN | JONES | QB | 11 | 201 | 289 | 69.6 | 2151 | 7.4 | 195.5 | 56 | 13 | 6 | 16 | 108 | 63.8 | 97.4 | |
| SAN | PURDY | QB | 8 | 178 | 257 | 69.3 | 2040 | 7.9 | 255 | 45 | 20 | 9 | 8 | 46 | 77.6 | 104.2 | |
| SEA | DARNOLD | QB | 16 | 303 | 451 | 67.2 | 3850 | 8.5 | 240.6 | 67 | 25 | 14 | 25 | 169 | 58.3 | 99.2 | |
| TB | MAYFIELD | QB | 16 | 327 | 521 | 62.8 | 3490 | 6.7 | 218.1 | 77 | 25 | 10 | 34 | 229 | 60.8 | 90.3 | |
| TEN | WARD | QB | 16 | 320 | 537 | 59.6 | 3117 | 5.8 | 194.8 | 47 | 15 | 7 | 55 | 410 | 32.1 | 79.8 | |
| WSH | MARIOTA | QB | 11 | 139 | 227 | 61.2 | 1695 | 7.5 | 154.1 | 56 | 10 | 7 | 16 | 107 | 49.8 | 86.1 | |
| WSH | DANIELS | QB | 7 | 114 | 188 | 60.6 | 1262 | 6.7 | 180.3 | 50 | 8 | 3 | 18 | 79 | 45 | 88.1 | |